21 results
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Algorithm Vascular Causes ... Gilbert's syndrome • Hemolysis ... (hemolysis, bleeding ... (hemolysis) • ... diagnosis #algorithm #hepatology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Thrombocytopenia ... of Pregnancy (AFLP ... defects. 1) HELLP (Hemolysis ... child * Severe cases ... #obstetrics #hematology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Thrombocytopenia ... defects. 1) HELLP (Hemolysis ... child * Severe cases ... TTPHUS #HELLP #AFLP ... Obstetrics #OBGyn #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... Diagnosis and Workup ... : INR/PT, aPTT(liver ... bypass), LFT (liver ... #Workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... microangiopathy: Thrombotic thrombocytopenic ... • Intrinsic RBC ... Extravascular #Causes ... differential #diagnosis #hematology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
(hemolysis, bleeding ... • LDH: Heart, RBC ... (hemolysis) • ... Gilbert's syndrome • Hemolysis ... #differential #Hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
disturbance (obstructed liver ... Highest • Bone • Liver ... Intestine - Other causes ... biliary Cholangitis (PBC ... Diagnosis #Algorithm #hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
HELLP Syndrome (Hemolysis ... clinical features: Hemolysis ... , Thrombocytopenia ... of Pregnancy (AFLP ... Disease #Pregnancy #hepatology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Schistocytes, thrombocytopenia ... ARUPConsult @ARUPLabs #Hemolytic ... Diagnosis #Algorithm #workup ... #hematology #testing
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... obstruction • ALP ... or higher • Liver ... cholangitis #diagnosis #workup ... #hepatology