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differential causes management treatment workup 1 agglutinin algorithm antibodies associations autoantibodies autoimmune cdi cdiff clostridioides clostridium cold difficile disease diseases
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... in bone marrow (BM ... of substrate (e.g ... under 2%, then BM ... #Workup #Hematology
Visceral Leishmaniasis - Diagnosis and Management Summary Species: Leishmania donovani, Leishmania infantum, Leishmania chagasi Where: South Asia, East
Leishmaniasis - Diagnosis ... Lymphohistiocytosis • Anemia ... histopathology, culture, PCR ... /d IV/IM 28-30 days ... management #treatment #infectiousdiseases
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Donath-Landsteiner Antibodies[PCH ... anemia • Cold ... - Mycoplasma, EBV ... Hemoglobinuria (PCH ... #hematology #diagnosis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
biliary cirrhosis (PBC ... - Vasculitis, e.g ... Celiac disease Anti-GBM ... Associations #diseases #diagnosis ... #table #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... function test, ANA (e.g ... changes), high MCV anemia ... When do you do a BM ... Causes #Workup #hematology
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
Infection (CDI) - Diagnosis ... Acute Diarrhea (>3 BM ... non-toxigenic • Stool PCR ... Bezlotoxumab 10 mg/kg ... management #treatment #infectiousdiseases
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential Diagnosis ... Constitutional disorders, eg ... replacing the BM ... Megaloblastic anemia-rare ... #causes #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
acute HIV, HBV, EBV ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia ... #differential #diagnosis ... #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Aldolase levels • EMG ... RP-ILD), dermato-rheumatologic ... • ANA < 20 % IBM ... Other Diseases: • PBC ... Myositis #Myopathy #rheumatology
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