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management agglutinin anemia antibodies apml associations autoantibodies autoimmune cdi cdiff clostridioides clostridium cold differential differentiation difficile disease diseases gastroenterology hemolytic
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Drug-induced SLE Anti-Jo-1 ... biliary cirrhosis (PBC ... Celiac disease Anti-GBM ... Associations #diseases #diagnosis ... #table #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Prednisone 5mg/kg ... symptoms, or> 1 ... fluid overload, PCC ... #management #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Antibodies: 1. ... Donath-Landsteiner Antibodies[PCH ... - Mycoplasma, EBV ... Hemoglobinuria (PCH ... hemolytic #anemia #hematology
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
Acute Diarrhea (>3 BM ... Epidemiology: • #1 ... non-toxigenic • Stool PCR ... Bezlotoxumab 10 mg/kg ... IV x 1 - Adjunct
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Ab • Anti-Jo-1 ... • ANA < 20 % IBM ... enzymes • Anti-Jo-1 ... Other Diseases: • PBC ... Myositis #Myopathy #rheumatology
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