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diagnosis management infectiousdiseases causes hematology 1 agglutinin aids anemia apml autoimmune bcnie bloodculture brain cauda caudaequina cdi cdiff clostridioides clostridium
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
Diagnosis- Compatible syndrome ... PCR 50% sensitive ... granulomatosis: • EBV-associated ... Lesions #Brain #differential ... causes #radiology #neurology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
hemorrhage • CSF PCR ... Toxoplasma gondii PCR ... • JC-virus PCR ... Enhancement • PCR ... #Infections #differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Donath-Landsteiner Antibodies[PCH ... Cold Agglutinin Syndrome ... - Mycoplasma, EBV ... younger pts) Differential ... Hemoglobinuria (PCH
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Coxsackie, HIV, CMV, EBV ... electromyographic (EMG ... #Weakness #Differential ... #Diagnosis #neurology
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
antiphospholipid syndrome ... special stains (e.g ... ribosomal RNA PCR ... - PCR for ... Endocarditis #diagnosis #differential
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework Viral Encephalitis: MCC: Enteroviruses (e.g., coxsackievirus
CNS Infections - ... Enteroviruses (e.g ... virus • CMV • EBV ... #Infections #differential ... #diagnosis #neurology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Prednisone 5mg/kg ... initiation • Differential ... Diagnosis: Infection ... fluid overload, PCC
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
life-threatening Differential ... Miller Fischer and PCB ... Serologic and EMG ... precipitated by: Drugs, infection ... diagnosis #management #neurology
Cauda Equina Syndrome Overview Cauda Equina Syndrome: • Prevalence: 1:33,000-100,000 ppl/yr • Incidence: 1.5-3.4 million ppl/yr •
lumbar spine • MCC ... (CES) is usually ... axial T1 and T2 Treatment ... #differential # ... diagnosis #causes #neurology
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
Clostridioides Difficile Infection ... Acute Diarrhea (>3 BM ... #1 nosocomial infection ... non-toxigenic • Stool PCR ... Bezlotoxumab 10 mg/kg
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