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differential management abnormal causes coagulation prolonged pt activation algorithm chronic cll defects dic disseminated evaluation inherited intravascular leukemia lymphocytic macrophage
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
: Is the PT or APTT ... K Antagonists, Heparin ... ) Step 3: Is a Systemic ... #prolonged #diagnosis ... #hematology #evaluation
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
- Differential Diagnosis ... TMA: Unexplained thrombocytopenia ... hemoglobin/hemosiderin, Hepatic ... hemosiderin • PT/aPTT ... Management #Algorithm #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
dysfunction (25%) • Hepatic ... 100mg/dL) - Heparin ... INR < 2.3 - APTT ... #Coagulation #diagnosis ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... thrombin inhibitors, heparin ... associated with systemic ... Prolonged #Causes #diagnosis ... #differential #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
unfractionated heparin ... cause e.g. heparin ... associated with systemic ... Prolonged #Causes #diagnosis ... #differential #hematology
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
receptor] • Thrombocytopenia ... sensorineural hearing ... Platelet #Defects #comparison ... #differential #diagnosis ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
leukopenia, anemia, and thrombocytopenia ... Hypofibrinogenemia • ↑ PT ↑ PTT ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... phenomenon CLL Diagnosis ... ’s CLL Scoring system ... Neutropenia, anemia, thrombocytopenia ... workup #oncology #hematology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
disorders, including systemic ... syndrome - IGG4 - Hepatic ... in LNs and the systemic ... Histopathological Diagnoses ... #management #rheumatology
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