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management differential treatment neurology rheumatology classification erythematosus hepatology infectiousdiseases leukemia lupus mds monoclonal myelodysplastic sle systemic abscess acromegaly agglutinin agraphia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... Management #treatment #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Clinical Presentation ... and petechiae Causes ... #oncology #hematology ... #diagnosis #management
Major neurocognitive disorders (MNCD): Diagnosis and workup 1) Clinical diagnosis Cognitive impairment + loss of autonomy 2)
1) Clinical diagnosis ... Alzheimer - 1st cause ... - Progressive amnesia ... Aphaso-apraxo-agnosia syndrome ... Dementia - 2nd cause
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
40 ml/min A - Anemia ... Causes of false- ... plasmacytoma, POEMs syndrome ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... formed or don’t work ... Workup: • Complete ... #diagnosis #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... • Neutropenia, anemia ... • Richter’s Syndrome ... #workup #oncology ... #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
WAIHA • CAD • PCH ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... fluid overload, PCC ... #management #hematology ... #oncology
Alexia Without Agraphia Alexia without agraphia is a disconnection syndrome where patients cannot read but can write.
disconnection syndrome ... the most common cause ... Pathophysiology: ... PCA Infarct (most ... #neurology #diagnosis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... • Symptoms of anemia ... anemia • Cold ... #hematology #diagnosis
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