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diagnosis management leukemia mds microscopy myelodysplastic smear workup algorithm anemia aplasia cancer cell chronic cll differentiation giant lymphocytic myelodysplasia parvovirus
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... = funny-shaped cells ... Management #treatment #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Anemia Clinical ... Constitutional Syndromes ... #Anemia #oncology ... #hematology #diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... • Induce blast cell ... Infection (sepsis), PE ... #management #hematology ... #oncology
A non-subtle example of true Sezary syndrome. Patient presented with erythroderma without antecedent history of
of true Sezary syndrome ... mjcascio #Sezary #Syndrome ... #Cells #Clinical ... #Pathology #Smear ... #Microscopy #Hematology
Pity this Giant Pronormoblast from an elderly pt w pure red cell aplasia. In the proper
pt w pure red cell ... aplasia. ... #Parvovirus #Pathology ... Smear #Microscopy #Hematology ... #Clinical
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... smear: Blasts APML ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... aplasia • ITP ... • Richter’s Syndrome ... diagnosis #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
transformation to AML ... Causes • Anemia • Aplastic ... progression to AML ... #diagnosis #hematology ... #oncology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Solitary Cell Plasmacytoma ... plasmacytoma) Clinical ... IFE, FLC assay Pathology ... #Plasmacytoma #Oncology ... Diagnosis #Workup #Hematology
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
Myelodysplastic syndromes ... Myelodysplastic syndromes ... with repeated red cell ... importance of clinical ... #algorithm #hematology
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