10 results
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
promyelocytic #leukemia #APL ... #APML #Pathology ... #Hematology #Clinical
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation ... Syndrome in APML ... Infection (sepsis), PE ... nsrosenberg #Differentiation ... #Syndrome #APML
Trichodysplasia spinulosa: follicles plugged w/ hyperkeratotic & parakeratotic debris, excessive inner root sheath differentiation towards keratinization.
inner root sheath differentiation ... Trichodysplasia #spinulosa #Pathology ... #Microscopy #Dermatology ... #Clinical
Hypersegmented neutrophil in a case of acute myeloid leukemia.

Dysplastic neutrophils are typically hypolobated but can be
#neutrophils #AML ... #Clinical #Hematology ... #Pathology #Smear
A non-subtle example of true Sezary syndrome.  Patient presented with erythroderma without antecedent history of
of true Sezary syndrome ... mjcascio #Sezary #Syndrome ... #Cells #Clinical ... #Pathology #Smear ... #Microscopy #Hematology
Nikolsky's Sign in Toxic Epidermal Necrolysis (TEN)

Nikolsky's sign is a clinical dermatological sign which is present
Nikolsky's sign is a clinical ... Stevens-Johnson Syndrome ... It is useful in differentiating ... Nikolskys #Sign #TEN #Dermatology ... PhysicalExam #Video #Clinical
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
impaired B-cell differentiation ... to 8 years Clinical ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... • Richter’s Syndrome ... Transform to DLBCL, PML ... leukemia • Sezary syndrome ... workup #oncology #hematology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Cryofibrinogenemia Clinical ... Diagnosis: • + Clinical ... Biopsy: Typical pathologic ... Antiphospholipid syndrome ... #rheumatology #hematology
Myelodysplastic syndromes current treatment algorithm 2018.

From Blood Cancer Journal, Published 24 May 2018

Myelodysplastic syndromes (MDS) are
Myelodysplastic syndromes ... Myelodysplastic syndromes ... cytopenias and AML ... importance of clinical ... #algorithm #hematology