9 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
infections, bone pain ... -> AML: Blast crises ... , fever, joint pain ... + distinctive primary ... #Hematology #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Non-Hodgkin's Lymphoma ... Reed-Sternberg Cells ... • Hodgkin's Lymphoma ... #Hematology #Oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Alcohol-induced pain ... : Pain in involved ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... hemolytic anemia • Pain ... Immunohistochemical studies (to differentiate ... classification #hematology ... #oncology #management
Chronic Abdominal Pain Causes - Differential Diagnosis Framework

Many patients with chronic abdominal pain have had prior
Causes - Differential ... dysfunction • PSC ... infarction • Lymphoma ... Ovarian CA Diffuse ... #Differential #
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Incidence: common in APL ... • Induce blast cell ... initiation • Differential ... fluid overload, PCC ... #oncology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... lymphoma • Evans ... the context of primary ... pneumonitis • Diffuse ... Arthritis: • Joint pain
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Amyloidosis • Lymphoma ... myeloma • Plasma cell ... Castleman disease • AL ... : Lymphoma, Leukemia ... Gap #ProteinGap #differential
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
presents with pain ... except for the primary ... UPEP, Serum IFE, FLC ... • Non-Hodgkin Lymphoma ... #Plasmacytoma #Oncology