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diagnosis erythematosus systemic ana anemia antibodies antinuclear druginduced drugs hemolytic hemophagocytic hlh lymphohistiocytosis medications patterns risk sjogrens summary syndrome tafro
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... • Blood smear: Differential ... #Autoimmune #Hemolytic ... Anemia #diagnosis #management ... #treatment #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
or Anti-NucIear Antibody ... Positive ANA ≠ Autoimmune ... Thyroid, Autoimmune ... ANA #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... disease • Non-autoimmune ... rheumatologic diseases ... deficiencies • Autoimmune
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Cytopenia +++ (Plt ... solid cancers • Autoimmune ... diseases: SLE++ ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
Induced Systemic Lupus ... for 1 year of treatment ... medications #drugs #pharmacology ... #risk #differential ... #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Adenocarcinoma Treatment ... lubricants • Pharmacologic ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
mesothelioma, etc - Autoimmune ... including systemic lupus ... erythematosus (SLE ... Hypoalbuminemia Treatment ... #rheumatology #
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