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diagnosis hematology differential algorithm oncology causes pbc primary cholangitis cirrhosis gastroenterology leukemia liver management pancytopenia psc alkaline alp approach bileduct
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis #pathophysiology #pbc #psc #hepatology #comparison
Disease: Primary Biliary ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... Definition • Pathophysiology ... @ZhuoerXie #Aplastic ... #Anemia #diagnosis ... #oncology #hematololgy
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Anemia - Underproduction ... - Anemia of chronic ... of chronic kidney ... Underproduction #Algorithm #hematology ... #differential #workup
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary ... Cirrhosis - Pathophysiology ... relative with PBC ... Pathophysiology ... #hepatology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
RBCs on Smear • Chronic ... Deficiency • Aplastic ... Anemia • Anemia ... of Chronic Disease ... Algorithm #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... mutations) • Immune Aplastic ... • ↓ WBC • ↓ PLT ... #hematology #diagnosis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... Pathophysiology ... No extrahepatic biliary ... cholangitis #diagnosis #workup ... #hepatology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... • Marrow Aplasia ... RA, SLE, PRV, Chronic ... #Normocytic #Anemia ... Algorithm #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
of chronic inflammation ... deficiency (including chronic ... deficiencies: Chronic ... marrow failure: Aplastic ... Production #Index #hematology
Causes of Biliary Dilatation - Differential Diagnosis • Physiological: ↑ Age, Cholecystectomy, Opioid dependence, Post-sphincterotomy •
Causes of Biliary ... AUPBD • Stones: Biliary ... Inflammatory: Chronic ... pancreatitis, PSC ... differential #diagnosis #hepatology
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