8 results
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Chronic Disease Normal ... Renal Disease, Liver ... #MCV #Classification ... #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach ... RBC Production - Normal ... #Classification ... Diagnosis #Algorithm #Causes ... #Hematology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary Cirrhosis ... intralobular bile ducts causes ... /Liver failure ... or higher • Liver ... diagnosis #workup #hepatology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
(Morphological Approach ... some patients) Normal ... : Alcohol use, Liver ... differential #diagnosis #causes ... #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Sarcoidosis) • Liver ... disease: Cirrhosis ... Thalassemia, Sickle cell anemia ... chain assay • An abnormal ... light chain • Normal
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Bile Ducts • PSC ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Algorithm Vascular Causes ... - If both are normal ... function may be abnormal ... hepatitis: < 1 • Cirrhosis ... diagnosis #algorithm #hepatology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
and petechiae Causes ... syndrome (MDS) (normal ... • ↓ WBC • ↓ PLT ... antithymocyte globulin ... #oncology #hematology