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hematology anticoagulant oral anticoagulation diagnosis oncology perioperative table apml chemotherapy cyp3a4 differentiation direct hemeonc heparin hit induced inducers inhibitors interactions
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet Novel (or Direct) Oral Anti-Coagulants • Rivaroxaban • Apixaban
NOAC / DOAC Pharmacology ... • Apixaban • Dabigatran ... #NOAC #DOAC #Pharmacology ... #Prescribing #hematology ... #management #Direct
Anticoagulants Common Reversal Agents - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra) - Heparin/LMWH
Anticoagulants Common Reversal ... Protamine sulfate - Dabigatran ... anticoagulation #doac ... #noac #pharmacology ... #hematology #reversal
DOAC Reversal Emergency surgery or urgent procedure Stop anticoagulant treatment; volume resuscitation and transfusion as needed Antidotes: • Apixaban,
DOAC Reversal Emergency ... anticoagulant treatment ... not available #DOAC ... #Reversal #NOAC ... #management #pharmacology
Oral Anticoagulation Management Cheat Sheet: Warfarin, Apixaban, Dabigatran, Rivaroxaban - Mechanism of Action - Routine Blood
Anticoagulation Management ... Warfarin, Apixaban, Dabigatran ... Adjustrnent - Reversal ... Anticoagulant #DOAC ... #Pharmacology #
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
(DOAC interactions ... ) Cancer-treatment ... Dabigatran has moderate ... content/133/4/291 #DOAC ... Interactions #Table #Pharmacology
Perioperative Management of DOACs Problem: ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Perioperative Management ... determine timing of DOAC ... of Therapy • Dabigatran ... postoperative #DOAC ... #Treatment #pharmacology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
heparin-PF4 complex → plt ... hypercoagulable state and plt ... including flushes), reverse ... , Bivalirudin, DOAC ... #Treatment #Hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... fluid overload, PCC ... to reverse coagulopathy ... Noah Rosenberg @ ... APML #diagnosis #management
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