12 results
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood ... Smear Analysis ... anemia Sickled ... #hematology #microscopy ... interpretation #clinical
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... DIC is a clinical ... arrow) Peripheral smear ... #anemia #Hematology ... #Pathology #Smear
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
smear showed numerous ... , a form of hemolytic ... inflexible and prone to hemolysis ... #NEJM #clinical ... #smear
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
smear or on bone ... - infiltrates (anemia ... • Peripheral smear ... more aggressive form ... #Hematology #Oncology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Hemoglobin Defects: Sickle ... cell anemia, Thalassemias ... - Peripheral Blood ... Smear ↑ abnormal
Howell-Jolly Body - On these Wright-stained peripheral blood smears the small dark spheres within red cells
smears the small ... autosplenectomy in sickle ... can be found in hemolytic ... , and leukemia. ... #Clinical #Path
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral Infection Clinical ... Immunoglobulin M (IgM) • Blood ... smear - RBC agglutination ... sensitize red blood ... #anemia #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... • Peripheral smear ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... workup #oncology #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Peripheral Smear ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... syndromes with single-lineage ... smear • Bone marrow
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Clinical Presentation ... virus (EBV) • Leukemia ... • ↓ WBC • ↓ PLT ... result from low blood ... #oncology #hematology