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hematology diagnosis oncology bloodsmear causes management microscopy analysis aplastic asplenia borrelia cell chronic cll coagulation dic differential disorders disseminated howell
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood ... Smear Analysis ... #Blood #Smear # ... Analysis #hematology ... interpretation #clinical
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or ... - infiltrates (anemia ... • Peripheral smear ... more aggressive form ... #Hematology #Oncology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... plateletcount), peripheral ... blood smear, HIV ... changes), high MCV anemia ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... cytometry • Peripheral ... smear: Smudge cells ... • Neutropenia, anemia ... #diagnosis #workup
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Smear: • Dysplastic ... • Hairy Cell Leukemia ... Workup: • Complete ... blood smear •
Howell-Jolly Body - On these Wright-stained peripheral blood smears the small dark spheres within red cells
Wright-stained peripheral ... blood smears the ... autosplenectomy in sickle ... thalassemia, and leukemia ... #Clinical #Path
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... virus (EBV) • Leukemia ... ) Labs: • Peripheral ... • ↓ WBC • ↓ PLT ... result from low blood
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... ABO incompatible blood ... organ damage Clinical ... D-Dimer: ↑ • Peripheral ... smear: Schistocytes
Borrelia recurrentis on Peripheral Blood Smear 23M Somali refugee recently arrived w/severe abd pain, confusion and fever
recurrentis on Peripheral ... Blood Smear 23M ... 12.5, WBC 14, Plt ... The table below ... microscopy #pathology #clinical
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
plasmacytoma) Clinical ... ridging around the periphery ... • No CRAB - no anemia ... Oncology #Diagnosis #Workup ... #Hematology
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