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hematology diagnosis oncology management algorithm analysis aplastic asplenia bloodsmear cancer causes chronic cll coagulation dic differential disseminated gap globulin howell
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood ... Smear Analysis ... Sickled red cells ... : Sickle cell disease ... interpretation #clinical
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... cell count (anemia ... Peripheral Smear ... Leukemia • Idiopathic ... Workup: • Complete
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
smear or on bone ... - infiltrates (anemia ... • Peripheral smear ... more aggressive form ... #Leukemia #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... • Peripheral smear ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... #diagnosis #workup
Howell-Jolly Body - On these Wright-stained peripheral blood smears the small dark spheres within red cells
smears the small ... autosplenectomy in sickle ... cell anemia. ... thalassemia, and leukemia ... #Clinical #Path
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... • Hypocellular myelodysplastic ... virus (EBV) • Leukemia ... • ↓ WBC • ↓ PLT ... result from low blood
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... ABO incompatible blood ... organ damage Clinical ... • Peripheral smear ... Schistocytes, helmet cells
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... myeloma • Plasma cell ... leukemia • Solitary ... , Thalassemia, Sickle ... cell anemia •
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
Myelodysplastic ... acute myeloid leukemia ... disease tolerate anemia ... with repeated red cell ... importance of clinical
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
can present as a single ... plasmacytoma) Clinical ... • No CRAB - no anemia ... Oncology #Diagnosis #Workup ... #Hematology
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