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hematology algorithm causes hemolysis hemolytic leukemia management chronic disorders extravascular intravascular lymphocytic mgus agglutinin blood classification cold differentiation disease erythematosus
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... - infiltrates (anemia ... ) CLL Symptoms: ... /Cytopenias • AIHA ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... • Neutropenia, anemia ... thrombocytopenia • AIHA ... #workup #oncology ... #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Acute • Myloid (AML ... CD10 - T-cell ... Pelger-Huet, Macrocytic anemia ... • Lymphoid (CLL ... - B-cell
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Increased red cell ... Increased red cell ... #Algorithm #Differential ... #Causes #Workup ... #Hematology #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... Transformation to large cell ... fludarabine) 3) Monoclonal ... uw_IMresidency #CLL ... Lymphocytic #Leukemia #oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoid malignancy (CLL ... malignancies -> CLL ... Diagnosis Monoclonal ... significance (MGUS), CLL ... #hematology #diagnosis
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
40 ml/min A - Anemia ... marrow plasma cell ... , B and T cell lymphoproliferative ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Diagnosis Algorithm ... • Sickle cell ... immune-complex hemolytic anemia ... #Diagnosis #Algorithm ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) (e.g. lupus, CLL ... Hemoglobinopathies (e.g. sickle cell ... Extravascular #Causes #differential ... #diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Organomegaly+↑RBC/plt ... (-) hemolytic anemia ... #Monoclonal #Differential ... #Diagnosis #Oncology
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