20 results
hematology differential management hemolytic leukemia testing causes chronic glomerular hemolysis mgus nephrology nephrotic agglutinin algorithm classification cold common cvid disorders
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... can indicate disease ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... Transformation to large cell ... fludarabine) 3) Monoclonal ... uw_IMresidency #CLL ... #Leukemia #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CLL Acute leukemias ... extramedullary disease ... - infiltrates (anemia ... /Cytopenias • AIHA ... #Oncology #Diagnosis
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
40 ml/min A - Anemia ... marrow plasma cell ... , B and T cell lymphoproliferative ... diseases, CML, ... #hematology #oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoid malignancy (CLL ... malignancies - B-cell ... malignancies -> CLL ... significance (MGUS), CLL ... #hematology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... - Autoimmune (AIHA ... ) (e.g. lupus, CLL ... Hemoglobinopathies (e.g. sickle cell ... #hematology #anemia
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
demineralization) • Renal disease ... hypercalcemia) • Anemia ... marrow plasma cells ... plasma clonal cell ... #Management #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... • Heavy Chain disease ... Organomegaly+↑RBC/plt ... (-) hemolytic anemia ... #Diagnosis #Oncology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... Autoimmune: Warm AIHA ... Defects: Sickle cell ... anemia, Thalassemias ... #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
No evidence of anemia ... insufficiency, Anemia ... to the plasma cell ... #Significance #hematology ... #diagnosis #oncology
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