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diagnosis hematology leukemia management monoclonal workup algorithm blood causes chronic classification differentiation gammopathy hodgkins lymphocytic lymphoma markers mds mgus myelodysplasia
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... Acute • Myloid (AML ... ) - PAS, TdT Lymphadenopathy ... #hematology #Markers ... #Differential #
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... activity • ↓ LAP ... count • ↓Hg & PLT ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Exam/Signs: • Lymphadenopathy ... lymphoproliferative disorders ... Transform to DLBCL, PML ... diagnosis #workup #oncology ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
• Induce blast cell ... initiation • Differential ... fluid overload, PCC ... diagnosis #management #hematology ... #oncology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... HCV testing - Lab ... not required in all ... #Differential # ... Causes #Workup #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Hematologic disorder ... hyperviscosity, lymphadenopathy ... to the plasma cell ... #Significance #hematology ... #diagnosis #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Organomegaly+↑RBC/plt ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... Neutropenia • Platelet Disorders ... compounds, alcohol, lead ... blood count with differential ... #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... • Autoimmune disorders ... Presentation: • Lymphadenopathy ... Immunohistochemical studies (to differentiate ... #oncology #management
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