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diagnosis hematology management leukemia cll lymphocytic mds myelodysplastic algorithm anemia aplastic apml differential differentiation hepatitis injury liver myelodysplasia syndromes workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Acute leukemias ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... microglobulin Treatment ... ’s lymphoma or acute ... diagnosis #workup #oncology ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... transformation to acute ... Allogeneic stem cell ... #hematology #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... transformation) Treatment ... #Chronic #Lymphocytic ... #Leukemia #oncology ... #hematology #hemeonc
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
vein: Budd-chiari syndrome ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... • Gilbert's syndrome ... diagnosis #algorithm #hepatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... • Induce blast cell ... fluid overload, PCC ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Marrow Failure • Chronic ... factor (GCSF) treatments ... marrow studies Treatment ... #diagnosis #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... • ↓ WBC • ↓ PLT ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
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