6 results
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Diagnosis Framework ... (>1000): • DILI ... injury) • Ischemic ... #Diagnosis #hepatology ... #transaminitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Injury (DILI) ... #differential # ... Diagnosis #Management ... gastroenterology #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
abnormality vs bone Bili ... Hepatocellular injury ... Hospital of Baltimore IM ... LFTs #Elevation #Transaminitis ... #diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... #differential # ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Unconjugated Bili ... > 90% of Total Bili ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
10x ULN), ↑Tbili/Dbili ... Cr, ↓Glucose, ↓PLT ... infiltration) Differential ... Diagnosis: Viral ... #Pregnancy #hepatology