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diagnosis differential algorithm hematology hepatitis injury obgyn obstetrics syndrome acidosis aflp aih autoimmune classification coagulation differentiation disseminated elevation fatty hbv
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... biliary obstruction ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Autoimmune hepatitis, PBC ... , PSC, IgG4, HLH ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... Triggers: ATRA treatment ... Imaging: CXR- pulmonary ... fluid overload, PCC ... #diagnosis #management
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... = nonspecific (nausea ... develops (DIC, ... Cr, ↓Glucose, ↓PLT ... #Pregnancy #hepatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... • Severe Liver ... Treat primary cause ... #treatment #management ... #hematology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
subclinical disease to acute ... liver failure ... reported (eg AIH-PBC ... regarding need for treatment ... #Hepatology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
Presence of CP or PC ... > 3 mg/dL) or acute ... liver failure ... #Indications #management ... #hepatology
Postpartum Hemorrhage - Differential Diagnosis and Management Uterine Atony (80%) - Most PPH Will respond to
Diagnosis and Management ... Oxytocin 40 IU in 1 liter ... hand to gather POC ... epinephrine prn DIC ... unresponsive to usual treatment
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
www.ncbi.nlm.nih.gov/pmc ... before beginning treatment ... cardiac output - Acute ... pulmonary edema ... peritonitis - Acute
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... vasculitis: 10%-16% Liver ... hepatitis, primary biliary ... Adenocarcinoma Treatment ... Rheumatology #Diagnosis #Management
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