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syndromes apml differentiation hematology mimics oncology prs rheumatology scleroderma sclerosis signs ssc symptoms syndrome systemic testing treatment workup
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
elbows/wrists and knees ... • Diffuse systemic ... proximally to arms ... : scleroderma renal ... #rheumatology #diagnosis
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Pulmonary Renal ... Diagnosis Framework ... Diffuse alveolar ... aureus infection, ARDS ... #Diagnosis
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... capillaritis leading to diffuse ... hemorrhage (DAH) • Diffuse ... #differential # ... diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Imaging: CXR- pulmonary ... initiation • Differential ... Anaphylaxis, Acute Renal ... fluid overload, PCC ... #management #hematology
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