10 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Cytopenia +++ (Plt ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary ... #rheumatology
Myocarditis 

5 Principles of
Myocarditis:
1. Build clinical suspicion
2. Decide on EMBx
3. Manage acute cardiac injury
4. Manage chronic
Pericarditis, Tamponade EKG ... Low voltage Treatment ... unclear - Giant Cell ... Myocarditis #diagnosis #management ... #cardiology #summary
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Pathophysiology ... • Induce blast cell ... Prednisone 5mg/kg ... APML #diagnosis #management ... #hematology #oncology
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
Related Disease Clinical ... increased IgG4+ cells ... Disease #diagnosis #management ... #phenotypes #workup ... #treatment #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... organ damage Clinical ... Schistocytes, helmet cells ... + Bleeding Treatment ... #management #hematology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Summary - GrepMed ... Handbook Clinical ... pancreatic islet cell ... Diagnosis and Workup ... Endocrinology #Treatment
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... Summary Epidemiology ... survival is 93-95% Pathophysiology ... renal failure Clinical ... anterior/posterior MSK
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
Diagnosis and Management ... Summary Epidemiology ... Person Syndrome Pathophysiology ... Clinical Manifestations ... antibody that works
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
Sclerosis (ALS) Summary ... lateral sclerosis Pathophysiology ... EMG: LMN Signs in ... diagnosis column Treatment ... neurology #diagnosis #management
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
plasmacytoma) Clinical ... red bone marrow, e.g ... Bone marrow Treatment ... Oncology #Diagnosis #Workup ... #Hematology