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diagnosis hepatology causes cirrhosis injury lfts primary abnormal acute alkaline alp cholangitis elevation erythematosus fat gap globulin hepatitis liverenzymes liverfunctiontests
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Ducts - PBC ... , PSC, Alcoholic ... stricture, PSC,
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
pregnancy Diagnose PBC ... Elevated ALP 2. ... Liver biopsy findings ... consistent with PBC ... #PBC #Primary
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... - Summary PBC ... 30-65 years PBC ... failure PBC ... • Fatigue PBC
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... Diagnosis Algorithm ... Cholangitis (PBC ... Infiltrative diseases - PSC ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune hepatitis, PBC ... , PSC, IgG4, HLH ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis ... specificity to elevated
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... Causes #Acute #algorithm ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Diagnosis Algorithm ... Bile Ducts • PSC ... Duct Stone • Biliary
Causes of Fat Malabsorption - Differential Diagnosis Biliary Duct Obstruction • Autoimmune— PBC, PSC • Infection— liver
Malabsorption - Differential ... Diagnosis Biliary ... • Autoimmune— PBC ... , PSC • Infection ... — liver fluke, HIV
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Sarcoidosis) • Liver ... autoimmune hepatitis, PBC ... , PSC, Viral hepatitis ... Gap #ProteinGap #differential ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Malignancy (e.g. hematologic ... sediment, and elevated ... Antiribosomal P, APLA, PAC ... • Malar rash - spares
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