19 results
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Wilsons, Pregnancy - AFLP ... Ducts - PBC ... , PSC, Alcoholic ... Biliary stricture, PSC ... #hepatology #LiverFunctionTests
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
(ALP) Elevation ... Algorithm ALP ... biliary Cholangitis (PBC ... Infiltrative diseases - PSC ... #Algorithm #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
ALP - Biliary ... Transaminase, ALP ... / ULN ALT) / (ALP ... Transaminitis #diagnosis ... #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... ) - Causes of Hepatocellular ... + ULN ALT) / (alkaline ... Transaminitis #diagnosis ... #differential #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Pregnancy - AFLP ... Bile Ducts • PSC ... #Hepatology #LiverEnzymes ... #Algorithm #Causes
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Autoimmune hepatitis, PBC ... , PSC, IgG4, HLH ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis ... #algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... Labs: • Alkaline ... obstruction • ALP ... or higher • Liver ... #workup #hepatology
Algorithm for the Diagnosis of Primary Biliary Cholangitis (PBC). 

US, ultrasound; MRCP, magnetic resonance cholangiopancreatography; ALP,
Biliary Cholangitis (PBC ... cholangiopancreatography; ALP ... , alkaline phosphatase ... #Cholangitis #PBC ... #Hepatology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
in 1923 Low ALP ... synthesized in: liver ... Most cases diagnosed ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... = nonspecific (nausea ... Cr, ↓Glucose, ↓PLT ... iMedEducation #AFLP ... Pregnancy #hepatology