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differential hematology antibodies associations autoantibodies cvid diseases gap globulin hypogammaglobulinemia immunodeficiency immunology malabsorption myopathy myositis protein proteingap variable
Causes of Fat Malabsorption - Differential Diagnosis Biliary Duct Obstruction • Autoimmune— PBC, PSC • Infection— liver
Causes of Fat Malabsorption ... - Differential Diagnosis ... — PBC, PSC • Infection ... — liver fluke, HIV ... #Causes
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Non-specific; common ... Dermatomyositis Anti-LKM (liver ... biliary cirrhosis (PBC ... Associations #diseases #diagnosis ... #table #rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... serum IgG level X2 at ... DDX - Other causes ... : • Nephrotic syndrome ... #diagnosis #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... Sarcoidosis) • Liver ... hepatitis, PBC, ... PSC, Viral hepatitis ... Comment on type
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Inflammatory Myopathies: Commonly ... RP-ILD), dermato-rheumatologic ... statins - probably caused ... Other Diseases: • PBC ... Myositis #Myopathy #rheumatology
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