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diagnosis hepatology algorithm elevation primary abscess acidosis acute alkaline alp children cirrhosis classification fatty hbv hepatitis hepatitisb hepbv indications lactate
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
) Elevation - Differential ... Intestine - Other causes ... Cholangitis (PBC ... Infiltrative diseases - PSC ... - Other biliary
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... Autoimmune hepatitis, PBC ... , PSC, IgG4, HLH ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... intralobular bile ducts causes ... obstruction • ALP ... or higher • Liver ... bile ducts Differential
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... #Injury #Differential
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
(PSC) PSC is a ... to multi-focal biliary ... colorectal and hepato-biliary ... disease management ... #diagnosis #management
Causes of Fat Malabsorption - Differential Diagnosis Biliary Duct Obstruction • Autoimmune— PBC, PSC • Infection— liver
Causes of Fat Malabsorption ... Diagnosis Biliary ... • Autoimmune— PBC ... , PSC • Infection ... — liver fluke, HIV
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Pregnancy - AFLP ... Bile Ducts • PSC ... Duct Stone • Biliary ... Diagnosis #Algorithm #Causes
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... metabolism accumulate → Fat ... = nonspecific (nausea ... Cr, ↓Glucose, ↓PLT ... infiltration) Differential
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
Presence of CP or PC ... transmission prophylaxis at ... injury (INR > 2 ... mg/dL) or acute liver ... #Indications #management
Pyogenic liver abscess in children Common bacterial causes in children: • S.aureus • Strep spp • Enteric
Common bacterial causes ... from contiguous focus ... perinephric abscess) • Biliary ... tree (cholangitis ... children #peds #differential
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