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diagnosis hepatology algorithm primary cholangitis elevation injury lfts rheumatology abnormal acidosis acute aih alkaline alp antibodies associations autoantibodies autoimmune classification
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... , Acute biliary ... Malignancy, 1° PBC ... , 1° PSC, Cystic
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... - Summary PBC ... 30-65 years PBC ... PBC Signs and ... #Cirrhosis #PBC
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... , PBC, PSC, IgG4 ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis ... : < 1 • Cirrhosis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Ducts - PBC ... , PSC, Alcoholic ... stricture, PSC,
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... Intestine - Other causes ... Cholangitis (PBC ... Infiltrative diseases - PSC ... - Other biliary
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
) PSC is a chronic ... • COVERT - PSC ... patients with PSC ... pathogenesis of PSC ... • CANCER - PSC
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Bile Ducts • PSC ... • Alcoholic hepatitis ... Infiltrative • Cirrhosis ... Duct Stone • Biliary
Causes of Fat Malabsorption - Differential Diagnosis Biliary Duct Obstruction • Autoimmune— PBC, PSC • Infection— liver
- Differential ... Diagnosis Biliary ... • Autoimmune— PBC ... , PSC • Infection ... — liver fluke, HIV
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
SLE, autoimmune hepatitis ... Dermatomyositis Anti-LKM (liver ... ) - Autoimmune hepatitis ... Anti-gp210 - Primary biliary ... cirrhosis (PBC)
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... Presence of CP or PC ... mg/dL) or acute liver ... failure #HepatitisB ... #Indications #management
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