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diagnosis differential oncology algorithm systemic treatment aplastic chronic cll generalized hemeonc lymphocytic myelodysplastic product pruritus reactions secondary transfusion workup acute
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Reactive: • Anemia ... /blood loss (Fe ... Chronic Myeloid Leukemia ... Differential #Diagnosis #causes ... #Platelets #hematology
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
promyelocytic leukemia ... (blood). ... features in most cases ... Kyle Bradley, MD ... APML #Pathology #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute leukemia ... Myelodysplastic #Syndrome #MDS ... #treatment #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Can progress to MDS ... or acute leukemia ... #diagnosis #management ... #treatment #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... -> AML: Blast crises ... - infiltrates (anemia ... CLL -> Invade Skin ... #Hematology #Oncology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Systemic and Primary Causes ... / Systemic == Blood ... renal failure/uremia ... • Lymphoma • Leukemia ... #generalized #dermatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Infection exposure (l MD ... plateletcount), peripheral blood ... changes), high MCV anemia ... or if a primary hematologic ... #Workup #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... and petechiae Causes ... virus (EBV) • Leukemia ... result from low blood ... #oncology #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
gammopathy, and skin ... autoimmune hepatitis, PBC ... , PSC, Viral hepatitis ... gastric tumors • Hematology ... differential #diagnosis #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... just beneath the skin ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... Syndromes #diagnosis #hematology
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