46 results
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
of associated autoimmune ... pregnancy Diagnose PBC ... specific ANAs (e.g ... consistent with PBC ... #PBC #Primary
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Other: NAFLD, Autoimmune ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... Acute #algorithm #hepatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
pattern: - SSc, PBC ... pattern: - PBC ... : - PBC, SSc ... , PBC/SSc OS, PBC ... SjS, SLE, RA, PBC
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
family history of autoimmune ... relative with PBC ... cell mediated autoimmune ... Cholestasis #PBC ... Pathophysiology #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Biliary Cirrhosis (PBC ... ) - Summary PBC ... 30-65 years PBC ... intralobular bile ducts causes ... patients • +ANA
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Intestine - Other causes ... Pruritis History and ... biliary Cholangitis (PBC ... Infiltrative diseases - PSC ... Diagnosis #Algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Ischemia • Autoimmune ... Bile Ducts • PSC ... • Cirrhosis (any ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
The 6 C’s of Primary Sclerosing Cholangitis (PSC)
PSC is a chronic, cholestatic, immune-mediated disease characterized by
) PSC is a chronic ... • COVERT - PSC ... liver disease management ... Cholangitis #diagnosis #management ... #summary #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Algorithm Vascular Causes ... : Autoimmune hepatitis ... , PBC, PSC, IgG4 ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Autoimmune Hepatitis ... reported (eg AIH-PBC ... BryanCUlrich #Autoimmune ... AIH #Diagnosis #Management ... #Hepatology