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diagnosis hepatology primary differential rheumatology algorithm biliary pbc treatment hepatitis psc sclerosing summary syndrome workup aih alkaline alp anemia antibodies
Primary sclerosing cholangitis (PSC) - Malignancy Screening and Surveillance Recommendations Cholangiocarcinoma - Annual US or
Primary sclerosing cholangitis ... (PSC) - Malignancy ... (with cirrhosis ... #PSC #Malignancy ... Gastroenterology #Management
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
(PBC) - Summary ... PBC Epidemiology ... 30-65 years PBC ... intralobular bile ducts causes ... #PBC #cholangitis
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
(PSC) PSC is a ... • CHOLANGITIS ... liver disease management ... #diagnosis #management ... #summary #Hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Primary Biliary Cirrhosis ... pregnancy Diagnose PBC ... specific ANAs (e.g ... consistent with PBC ... #PBC #Primary
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary Cirrhosis ... relative with PBC ... cell mediated autoimmune ... Cholestasis #PBC ... Pathophysiology #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Intestine - Other causes ... Pruritis History and ... Primary biliary Cholangitis ... (PBC) - Other ... Infiltrative diseases - PSC
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
• Ischemia • Autoimmune ... Bile Ducts • PSC ... Infiltrative • Cirrhosis ... (any) • Congenital ... Diagnosis #Algorithm #Causes
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
common in SLE, autoimmune ... microsomal) - Autoimmune ... Primary biliary cirrhosis ... (PBC) Anticentromere ... diagnosis #table #rheumatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... , PBC, PSC, IgG4 ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis ... hepatitis: < 1 • Cirrhosis
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... reported (eg AIH-PBC ... : Auto-Nuclear ANA ... AIH #Diagnosis #Management ... #Hepatology
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