18 results
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody Testing ... • Reticular/AMA ... , PBC/SSc OS, PBC ... /SjS OS - AMA ... ARUPConsult @ARUPLabs #ANA
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... progresses • +AMA ... 1.5 x ULN • AMA ... cholangitis #diagnosis #workup ... #hepatology
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Multi-system autoimmune ... proximally to arms ... pericarditis • Hepatic: PBC ... signs #symptoms #testing ... #workup
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Autoimmune Hepatitis ... reported (eg AIH-PBC ... : Auto-Nuclear ANA ... AIH #Diagnosis #Management ... #Hepatology
Acute Altered Mental Status - Rapid Response Management

1) Ask while en route: vitals, hyper/hypoactive, POC glucose,
hyper/hypoactive, POC ... stabilize: AMS ... Workup 5) Treat ... the underlying cause ... #criticalcare #
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... Spot PC (protein ... same information as ... infections are common causes ... #workup #diagnosis
Predicting an anatomically and/or physiologically challenging airway is not a straightforward task by any stretch of
elective surgery setting ... as applicable to ... emergency airway management ... prediction models only focus ... Diagnosis #EM #PCC
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
cell adhesion and ... fluid overload, PCC ... coagulopathy, RRT/IMV as ... APML #diagnosis #management ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... Cirrhosis, ETOH, autoimmune ... hepatitis, PBC, ... PSC, Viral hepatitis ... gastric tumors • Hematology
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... Spot PC (protein ... same information as ... infections are common causes ... glomerular #disease #workup