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diagnosis differential rheumatology hepatology algorithm injury liver acute anemia aplastic apml associations autoantibodies biliary cholangitis differentiation diseases erythematosus gap globulin
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
common in SLE, autoimmune ... microsomal) - Autoimmune ... Primary biliary cirrhosis ... (PBC) Anticentromere ... #antibodies
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
(PBC) - Summary ... PBC Epidemiology ... 30-65 years PBC ... intralobular bile ducts causes ... • Antithyroid antibodies
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Other: NAFLD, Autoimmune ... obstruction, HELLP Syndrome ... Malignancy, 1° PBC ... , 1° PSC, Cystic
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
• Ischemia • Autoimmune ... Bile Ducts • PSC ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... , PBC, PSC, IgG4 ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis ... hepatitis: < 1 • Cirrhosis
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis is an autoimmune ... Hodgkin lymphoma - Autoimmune ... Labs: - AchR antibodies ... - LRP4 antibodies ... Gravis #diagnosis #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Hypocomplementemia • Can cause ... primary biliary cirrhosis ... Nephrogenic DI Hematologic ... Diagnosis #Management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... fluid overload, PCC ... Differentiation #Syndrome ... APML #diagnosis #management ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... Liver disease: Cirrhosis ... , ETOH, autoimmune ... hepatitis, PBC, ... PSC, Viral hepatitis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
disease • Non-autoimmune ... Malignancy (e.g. hematologic ... deficiencies • Autoimmune ... Antiribosomal P, APLA, PAC ... 1, SCL-70, RNP antibodies
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