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hepatology algorithm differential rheumatology biliary cholangitis pbc treatment antibodies associations autoantibodies chagas disease diseases gap globulin hemophagocytic hepatitis hlh injury
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Cirrhosis - Diagnosis ... PBC if 2/3 criteria ... consistent with PBC ... #PBC #Primary ... #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... - Summary PBC ... 30-65 years PBC ... intralobular bile ducts causes ... #hepatology
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
The 6 C’s of Primary ... asymptomatic at diagnosis ... #Primary #Sclerosing ... #management #summary ... #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
- Differential Diagnosis ... • Ischemia • Autoimmune ... Bile Ducts • PSC ... Infiltrative • Cirrhosis ... #Algorithm #Causes
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
, Anti-gp210 - Primary ... biliary cirrhosis ... (PBC) Anticentromere ... Associations #diseases #diagnosis ... #table #rheumatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... , PBC, PSC, IgG4 ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis ... hepatitis: < 1 • Cirrhosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Cytopenia +++ (Plt ... assessment+++ Primary ... solid cancers • Autoimmune ... #management #treatment ... #summary #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Liver disease: Cirrhosis ... , ETOH, autoimmune ... hepatitis, PBC, ... PSC, Viral hepatitis ... #differential #diagnosis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Hypocomplementemia • Can cause ... biliary cirrhosis ... Nephrogenic DI Hematologic ... #Diagnosis #Management
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary Chagas disease (American trypanosomiasis) is an infectious
and Management ... Summary Chagas ... infectious disease caused ... others: AV blocks, PVC ... cruzi Treatment - Primary
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