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diagnosis rheumatology hemophagocytic hlh lymphohistiocytosis algorithm biliary cholangitis differential erythematosus hemeonc hepatology lupus myopathy myositis pbc pruritus scleroderma sclerosis signs
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis ... autoimmune disease ... pericarditis • Hepatic: PBC ... (primary biliary ... Scleroderma #SSc #rheumatology
Proposed Schema for the Management of Pruritus in Primary Biliary Cholangitis (PBC). Cholestyramine up to 4g
of Pruritus in Primary ... Biliary Cholangitis (PBC ... Recirculating System ... #Cholangitis #PBC ... #Management #Hepatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Cytopenia +++ (Plt ... assessment+++ Primary ... solid cancers • Autoimmune ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Vaginal dryness • Primary ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... #Diagnosis #Management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... disease • Non-autoimmune ... the context of primary ... deficiencies • Autoimmune ... Antiribosomal P, APLA, PAC
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... of the immune system ... Types of HLH • Primary ... Malignancies ▪ Autoimmune ... #Hematology #HemeOnc
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... • Conduction system ... statins - probably caused ... Other Diseases: • PBC ... Myositis #Myopathy #rheumatology
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