14 results
The 6 C’s of Primary Sclerosing Cholangitis (PSC)
PSC is a chronic, cholestatic, immune-mediated disease characterized by
to multi-focal biliary ... asymptomatic at diagnosis ... with persistently active ... colorectal and hepato-biliary ... #Cholangitis #diagnosis
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Anti-gp210 - Primary biliary ... cirrhosis (PBC) ... Associations #diseases #diagnosis ... #table #rheumatology
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
pericarditis • Hepatic: PBC ... (primary biliary ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
reported (eg AIH-PBC ... Diagnosis - If suspected ... , AIH diagnosis ... regarding need for treatment ... azathioprine (check TPMT activity
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Tuberculosis Diagnosis ... staining, NAA (PCR ... Tuberculosis Treatment ... Tuberculosis #TB #Diagnosis ... #Management #Treatment
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... opacities • Diagnosis ... Renal Failure Treatment ... fluid overload, PCC ... #management #hematology
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Tuberculosis Diagnosis ... staining, NAA (PCR ... Tuberculosis Treatment ... Tuberculosis #TB #Diagnosis ... #Management #Treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
absent NK cell activity ... • Bicytopenia Treatment ... rapidly, and empiric antibiotic ... #management #treatment ... #hematology
Sulfonamides - Antibiotics Class Overview

BACTRIM/SEPTRA (TMP/SMX) - inhibit sequential steps in Folate synthesis --> bacteriostatic

Spectrum: Wide
Sulfonamides - Antibiotics ... other agents are: activity ... purposes including PCP ... choice, both for treatment ... #Pharmacology #Antibiotics
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... Antiribosomal P, APLA, PAC ... Erythematosus #Diagnosis ... #Rheumatology