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diagnosis treatment emergencies leukemia oncologic anemia aplastic cancer cardiology cardiotoxicity checkpoint chronic cll differential differentiation hemeonc hepatology hepatopulmonary ici inhibitor
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... fluid overload, PCC ... #management #hematology ... #oncology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Diagnosis Framework HEMATOLOGIC ... Hyperviscosity Syndrome ... • Dyspnea at rest ... • Chest and shoulder ... : Tumor Lysis Syndrome
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... smear: Blasts APML ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Polycythemia Vera (PV) - Diagnosis and Management Summary Diagnostic Criteria: • Elevated hemoglobin and/or hematocrit AND •
Diagnosis and Management ... transformation into AML ... of symptoms and prevention ... aspirin • Aspirin should ... Summary #treatment #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... • ↓ WBC • ↓ PLT ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... ): - Hematologic ... weakness, urinary retention ... : - Seen with AML ... (~20 %) and APL
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... • Richter’s Syndrome ... Transform to DLBCL, PML ... diagnosis #workup #oncology ... #hematology
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... Should be performed ... 10 minutes of rest ... hepatopulmonary #syndrome ... #treatment #hepatology
Management of Immune Checkpoint Inhibitor (ICI) Induced Cardiotoxicity Problem - Immune checkpoint inhibitors (ICIs) are associated with
strategies for prevention ... initiation of steroids should ... Corticosteroids should ... abnormal screening tests ... Cardiotoxicity #cardiology #oncology
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