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nephrology differential hyponatremia causes gitelman pathophysiology acute alkalosis bartter hypotonic injury kidney low management metabolic physiologic table urinary urine
Algorithm for Differentiating Gitelman syndrome from Bartter syndrome • Urine Chloride • Urine Ca/Cr ratio Dr. Krithika
Algorithm for Differentiating ... • Urine Chloride ... #Bartter #Algorithm ... #nephrology #hypokalemia ... #diagnosis
Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
- Differential Diagnosis ... Algorithm Syndrome ... Pain/Post-op • Neurologic ... Malignancy True hypovolemia ... • Reduced GFR, AKI
Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
- Differential Diagnosis ... Algorithm Syndrome ... Pain/Post-op • Neurologic ... Malignancy True hypovolemia ... • Reduced GFR, AKI
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... thiazide-sensitive sodium-chloride ... H+ secretion → Hypokalemia ... Pathophysiology #nephrology ... #diagnosis
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
Algorithm Cl- ... , Gitelman syndrome ... the excretion of sodium ... #urine #Algorithm ... #diagnosis
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
thiazide-sensitive sodium ... chloride cotransporter ... thiazide-sensitive sodium ... chloride cotransporter ... #diagnosis #nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Kidney Injury (AKI ... Pre-Renal: • Hypovolemia ... Abdominal Compartment Syndrome ... #nephrology #causes ... #algorithm
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... Present (Uosm ≥100): Hypovolemia ... Cirrhosis, Nephrotic syndrome ... #differential #diagnosis ... #nephrology
Modified Hyponatremia Algorithm Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants Hypotonic Hyponatremia: • ADH ON (UOsm > 100):
Modified Hyponatremia Algorithm ... ON (UNa < 30): Hypovolemia ... Cirrhosis, Nephrotic syndrome ... #diagnosis #sodium ... #nephrology
Hyponatremia - Differential Algorithm Isotonic Hyponatremia: Hyperlipidemia, Hyperproteinemia, Recent TURP Hypotonic Hyponatremia: • Hypovolemia: Diuretics/Nephropathies, Vomiting, Diarrhea,
- Differential Algorithm ... Hyponatremia: • Hypovolemia ... Cirrhosis, Nephrotic Syndrome ... #diagnosis #causes ... #nephrology #sodium
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