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diagnosis management reactions dermatomyositis product transfusion antimda5 antimda5dm antinxp2 antinxp2dm coagulation comparison cryofibrinogenemia differential disseminated dyspnea intravascular leukemia oncology sjogrens
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Tamponade Pulmonary ... - Water - Pus ... - Blood • Pleura ... Transverse myelitis • Hematology ... #pulmonary
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... organ damage Clinical ... Treat primary cause ... Coagulation #diagnosis #causes ... treatment #management #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
which can plug blood ... thrombophlebitis, pulmonary ... skin necrosis • DIC ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... Blast cells - Blood ... -> AML: Blast crises ... Fibrinolysis & DIC ... #Leukemia #Hematology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
Risk factors: Critical ... of high parity blood ... without other cause ... , and CXR with pulmonary ... Transfusion #Reactions #hematology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
auricular papules Clinical ... onset [33-74%] • Blood ... anti-NXP2 Abs Lung ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
pain, dark urine, DIC ... Causes purpura & ... Related Acute Lung ... TRALI): Leading cause ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
pain, dark urine, DIC ... Causes purpura & ... Related Acute Lung ... TRALI): Leading cause ... diagnosis #management #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
salivary ducts Clinical ... • Nephrogenic DI ... Hematologic: ... MALT Lymphoma • Lung ... Sjogrens #Syndrome #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
subcutaneous edema Pts ... auricular papules Clinical ... Muscle atrophy may cause ... diagnosis #management #rheumatology ... #dermatology
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