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diagnosis coagulation differential management prolonged abnormal algorithm disorders platelet ptt treatment activation anticoagulant apixaban bruising cancer cascade clot dabigatran dic
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PTT, Normal PT ... (INR) - Bleeding ... ) - No Bleeding ... #Hematology #coagulation
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Step 1: Is the PT ... K Antagonists, Heparin ... Prolonging the PT ... to identify the cause ... prolonged #diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... Fibrinogen: ↓ • PT ... Treat primary cause ... INR < 2.3 - APTT ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... PT and the aPTT ... (e.g. heparin contamination ... thrombin inhibitors, heparin ... #differential #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... unfractionated heparin ... e.g. heparin ... #differential #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- History of bleeding ... epistaxis, gingival bleeding ... : INR/PT, aPTT(liver ... or if a primary hematologic ... #Workup #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... mixing study (aPTT ... normal in mild cases ... ) • PT/INR & von ... Management #treatment #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... • Bleeding gums ... Acquired: • Heparin ... discern these causes ... Differential #Diagnosis #Hematology
Treatment algorithm for VTE in Malignancy (A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
at high risk of bleeding ... low-molecular-weight heparin ... Cancer #Algorithm #Anticoagulation ... #Management #Hematology ... #Oncology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
thrombin #clot #PT ... #PTT #diagnosis ... #models #hematology ... pathophysiology #anticoagulation ... Rivaroxaban #Edoxaban #heparin
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