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diagnosis differential abnormal coagulation pt bleeding bruising dermatology disseminated evaluation hemostasis intravascular leukemia management mixing nonpalpable palpable ptt purpura rheumatology
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Artifactually Prolonged ... K Antagonists, Heparin ... to identify the cause ... of Prolonged APTT ... #hematology #evaluation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... e.g. heparin ... intravascular coagulation (DIC ... #Prolonged #Causes ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
(e.g. heparin contamination ... thrombin inhibitors, heparin ... intravascularcoagulation (DIC ... #Prolonged #Causes ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... Treat primary cause ... INR < 2.3 - APTT ... Coagulation #diagnosis #causes ... treatment #management #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
marrow disease - DIC ... deficiencies - PNH ... Purpura Fulminans (DIC ... Cholesterol emboli • Septic ... Differential #Diagnosis #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Acquired: • Heparin ... the PT remains prolonged ... discern these causes ... disease • Acute DIC ... Differential #Diagnosis #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... count ↑ PLT • ↑ PBS ... Fibrinolysis & DIC ... #Leukemia #Hematology ... #Oncology #Diagnosis
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