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diagnosis differential abnormal aptt pt arterial bleeding dermatology dic disseminated embolism hemostasis intravascular leukemia management nonpalpable palpable pathophysiology purpura rheumatology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... unfractionated heparin ... e.g. heparin ... #differential #hematology ... #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... Treat primary cause ... 100mg/dL) - Heparin ... #diagnosis #causes ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Diagnosis for a Prolonged ... (e.g. heparin contamination ... thrombin inhibitors, heparin ... #differential #hematology ... #coagulation
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
vascular disorders, coagulation ... Platelet defects • Coagulation ... deficiencies - PNH ... Cholesterol emboli • Septic ... Differential #Diagnosis #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Hyperhomocysteinemia - Heparin-induced ... intravascular coagulation ... and other causes ... - COVID-19 - PNH ... pathophysiology #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... Acquired: • Heparin ... the PT remains prolonged ... discern these causes ... Differential #Diagnosis #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
mass • Rapidly rising ... -> AML: Blast crises ... PLT: Petechiae, bruising ... #Leukemia #Hematology ... #Oncology #Diagnosis
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