9 results
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
to Evaluate an Abnormal ... K Antagonists, Heparin ... to identify the cause ... ISNeducation #Abnormal ... #diagnosis #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... unfractionated heparin ... e.g. heparin ... Jcortesizaguirr #Abnormal ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Diagnosis for a Prolonged ... (e.g. heparin contamination ... thrombin inhibitors, heparin ... amyloidosis #Abnormal ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Thrombocytopenia • Prolonged ... Treat primary cause ... 100mg/dL) - Heparin ... Coagulation #diagnosis #causes ... treatment #management #hematology
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
muscle spasms lead ... invade URT & via hematologic ... , altered LOC; septic ... CNS and hematologic ... genital warts, abnormal
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
Acquired: • Heparin ... the PT remains prolonged ... PT/ABNORMAL PTT ... discern these causes ... Differential #Diagnosis #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP ... -> AML: Blast crises ... count ↑ PLT • ↑ PBS ... #Leukemia #Hematology ... #Oncology #Diagnosis
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
an underlying cause ... Better call hematology ... JAK2 V617F) and MPNs ... about secondary causes ... Algorithm #workup #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... skin that are caused ... compounds, alcohol, lead ... Syndromes #diagnosis #hematology ... #oncology