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diagnosis differential dermatology erythematosus management sle systemic vasculitis anemia antinxp2 antinxp2dm autoimmune cerebritis classification cns dermatomyositis extravascular hemolysis hemolytic intravascular
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Demyelinating Syndrome ... autoantibodies that will cause ... Erythematosus #SLE #CNS ... #neurology #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... hemoglobinuria (PNH ... usually IgG) (e.g. lupus ... differential #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... lower extremity edema ... • May involve PNS ... Erythematosus #Diagnosis #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Scleromyxedema (CNS ... Amyloidosis (CVS+PNS ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Episcleritis Signs ... Causes: - Idiopathic ... , breast CA - Hematologic ... - Lupus - Leukemia ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... inflammation Others: • Lupus ... such as systemic lupus ... purpura: strong sign ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... tract, and often causes ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome ... Differential #Diagnosis #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Pts have more ... chest (in a V-sign ... shoulders (in a shawl sign ... Muscle atrophy may cause ... diagnosis #management #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... papules and Gottron sign ... ) • Shawl sign ... statins - probably caused ... Myositis #Myopathy #rheumatology
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