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diagnosis lupus differential sle systemic treatment dermatology activation algorithm ana antinuclear antinxp2 antinxp2dm autoimmune capillary cardiology cerebritis chf clarksons clinical
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... the formation of autoantibodies ... that will cause ... #rheumatology # ... cerebritis #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Anti-Ro/SSA autoantibodies ... Non-autoimmune rheumatologic ... lower extremity edema ... • May involve PNS ... #Diagnosis #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Systemic lupus erythematosus ... nervous system (CNS ... systemic lupus erythematosus ... #Diagnosis #Management ... #Hematology #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... months) and of autoantibodies ... Systemic Lupus Erythematosus ... sle #comparison #table ... #rheumatology #
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
SLE-SSc-AlM overlap syndromes ... #Antinuclear #autoantibodies ... Systemic #lupus #erythematosus ... #diagnosis #rheumatology ... #table #ANA
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
blisters containing pus ... Rule out other causes ... #Rheumatology # ... diagnosis #management ... #Dermatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Pts have more ... without these autoantibodies ... Muscle atrophy may cause ... Dermatomyositis #diagnosis #management ... #rheumatology #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... #Rheumatology # ... Diagnosis #Management
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Capillary leak syndrome ... pain, Diffuse edema ... risk of pulmonary edema ... #diagnosis #management ... timeline #treatment #rheumatology
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
JVD, Orthopnea/PND ... acute coronary syndrome ... the determined cause ... differential #algorithm #management ... cardiology #treatment #table
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