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diagnosis rheumatology syndrome treatment differential lupus erythematosus activation algorithm antinxp2 antinxp2dm cardiomyopathy cerebritis comparison dermatomyositis dress druginduced hemophagocytic hlh hyperkalemia
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... of Systemic Lupus ... autoantibodies that will cause ... #CNS #neurology ... cerebritis #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Classified among the secondary ... (CNS) dysfunction ... Petechial or purpuric rash ... erythematosus [SLE ... #Hematology #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Malignancy (e.g. hematologic ... lower extremity edema ... • May involve PNS ... and CNS • Headache
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... months to years) Systemic ... #comparison #table ... #rheumatology # ... diagnosis #management
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
Eosinophilia and Systemic ... extensive skin rash ... • Facial Edema ... in 70% of cases ... DRESS #Syndrome #dermatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
other diseases • Secondary ... overlaps with RA, SLE ... Parotid swelling CNS ... (CNS): demyelinating ... • 8%-27% for CNS
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... -> AML: Blast crises ... leukostasis syndrome: CNS ... bone marrow and secondary ... #Leukemia #Hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
frequently affected systems ... Better call hematology ... some time, let’s see ... causes: Many of ... Algorithm #workup #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
(depending on CNS ... transplantation Secondary ... Options for severe cases ... HLH #Treatment #management ... #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... , mucositis • Rash ... tract, and often causes ... chorioretinitis, CNS ... Differential #Diagnosis #Rheumatology
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