21 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... fever • Drug reactions ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
for secondary causes ... eosinophilia (common causes ... allergy, drug reaction ... symptoms (eg, skin ... Differential #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... Other: Transfusion reaction ... hemoglobinuria (PNH ... Extravascular #Causes ... differential #diagnosis #hematology
If you haven't seen it, flecainide can cause significant yellowing of the skin and eyes.
flecainide can cause ... yellowing of the skin ... sideeffects #clinical #photo ... #nails #cardiology ... #dermatology #discoloration
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... include: fever, cutaneous ... infections with skin ... diagnosis #management #hematology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
DERMATOMYOSITIS Cutaneous ... ulcerations • Skin ... • Skin vasculopathies ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Alpha & Mu) Skin ... gangrenosum • Cutaneous ... thrombosis+Pulm HTN+skin ... Amyloidosis (CVS+PNS ... Paraproteinemias #Hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Testosterone - Coumadin skin ... considered in all cases ... coagulation and other causes ... - COVID-19 - PNH ... pathophysiology #hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... include: fever, cutaneous ... infections with skin ... diagnosis #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Thromboembolism (7%) • CNS ... involvement (2%) Cutaneous ... Treat primary cause ... Coagulation #diagnosis #causes ... treatment #management #hematology