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diagnosis differential alkaline arterial clinical crypto cryptococcal embolism emergencies hemeonc hepatology hyophosphatasia low mds meningitis mri myelodysplasia myelodysplastic oncologic phosphatase
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... -> AML: Blast crises ... count ↑ PLT • ↑ PBS ... Transformation: • Complication ... #Hematology #Oncology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
prematurely • risk ... membrane into the CNS ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Acquired Risk ... considered in all ... cardiovascular risk ... Venous #Arterial #pathophysiology ... #hematology #differential
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology Pulse pressure is the difference between the systolic blood
Diagnosis and Pathophysiology ... • Sepsis Complications ... • Mitchell et al ... • Increased risk ... #causes #cardiology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
carries a variable risk ... • Hairy Cell Leukemia ... and reducing the risk ... Syndromes #diagnosis #hematology ... #oncology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
syndrome): - Hematologic ... mg/dL or > 25 % rise ... Treat underlying cause ... Usually myeloid leukemias ... AML (~20 %) and APL
Cryptococcal meningitis on T2 MRI 30 M from sub-Saharan Africa presents w/ progressive Headache x1 mo, +neck
Nausea & vomiting ... If a second LP is ... performed, relative risk ... have a higher risk ... meningitis #T2 #MRI #Brain
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