17 results
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... old, ~10,000 new cases ... • Risks: infection ... Management #treatment #hematology ... #oncology
Algorithm for evaluating multiple ring-enhancing lesions in immunocompetent (HIV negative)

#ringenhancing #lesions #cns #brain #diagnosis #differential #algorithm
ringenhancing #lesions #cns ... #brain #diagnosis ... differential #algorithm #causes ... #radiology #neurology
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent
Multiple Ring-Enhancing Lesions:
 • Toxoplasmosis (CD4 < 100)
 • Other
CNS Ring-Enhancing ... + toxo IgG • CNS ... 30% present w/ CNS ... @AnnKumfer #CNS ... #causes #radiology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... autoantibodies that will cause ... thrombosis and/or blood-brain ... Erythematosus #SLE #CNS ... #neurology #rheumatology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... carries a variable risk ... and reducing the risk ... #Syndromes #diagnosis ... #hematology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... -> AML: Blast crises ... leukostasis syndrome: CNS ... #Leukemia #Hematology ... #Oncology #Diagnosis
Leigh Syndrome 
History: 19-month-old girl with hypotonia, developmental 
delay, failure to thrive, and bilateral optic disc
subthalamic nuclei, pons ... patterns (this case ... Clinical #MRI #Brain ... #Diagnosis #Radiology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... Parotid swelling CNS ... nervous system (CNS ... • 8%-27% for CNS ... Nephrogenic DI Hematologic
Common MRI Sequences - Basic MRI Brain Interpretation

 • T1 Sequence - T1 is for anatomy.
barrier- but masses ... give contrast, masses ... hematomas and pus ... MRI #Sequences #Radiology ... Neuroradiology #diagnosis
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... prematurely • risk ... membrane into the CNS ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology